Following the sequencing of the human genome, efforts have now moved to increasing understanding of the complex role human genes play in health and disease. While genomic variation partly defines our individuality, changes in the 3 billion bases of the human genome or changes in the genes 'expressed' may also result in disease. Surprisingly, most of the human genome does not have an obvious functional role. Only about 1% is protein coding genes, but an additional 4% of the genome is under evolutionary constraint. My group is analysing these regions to identify critical regions.
These data are currently being integrated into an open-access database system, which will also include online tools for data analysis to understand this system. The database will focus on providing New Zealand genomics researchers with the ability to store, share and analyse genomic data relevant to human health and disease, and will be made available via the Kiwi Advanced Research and Education Network (KAREN).
Last modified: Thursday, 28-Jul-2005 17:23:30 NZST
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